In collaboration with colleagues at the National Institute on Alcohol Abuse and Alcoholism, the National Institute for Mental Health, the University of Southern California, and the University of Utah, we have used transgenic mice to investigate the roles of alterations in the serotonergic and glutamatergic systems in increased risk for neuropsychiatric disease as well as contributions of these neurotransmitter systems in stress-induced dendritic changes.  These studies provide data relevant for understanding the neurobiological mechanisms underlying both altered corticolimbic function and risk for mood disorders in the presence of environmental stressors.