Journal Articles
Harshaw, C., Kojima, S., Wellman, C.L., Demas, G.E., Morrow, A.L., Taft, D.H., Kenkel, W., Leffel, J.K., & Alberts, J.R. (2022). Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice. Developmental Psychobiology, 64, e22289.
Cusick, J.A., Wellman, C.L., & Demas, G.E. (2022). Maternal Stress and the Maternal Microbiome Have Sex-Specific Effects on Offspring Development and Aggressive Behavior in Siberian Hamsters (Phodopus sungorus). Hormones & Behavior, 141, 105146.
Adaniya, C.H., Wellman, C.L., Demas, G.E., & Cusick, J.A. (2021). The ontogeny of personality: Repeatability of social and escape behaviors across developmental stages in Siberian hamsters (Phodopus sungorus). Journal of Experimental Zoology, Part A: Ecological Genetics and Physiology, 335, 564-571. doi: 10.1002/jez.2499.
Cusick, J.A., Wellman, C.L., & Demas, G.E. (2021). The call of the wild: Using non-model systems to quantify microbiome-behaviour relationships. Journal of Experimental Biology, 224, jeb224485. doi:10.1242/jeb.224485.
De Falco E., White S.M., Morningstar M.D., Ma B., Nkurunziza, L.T., Ahmed-Dilibe, A., Wellman C.L., & Lapish C.C. (2021). Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking. Addiction Biology, 26, e13004. https://doi.org/10.1111/adb.13004.
Moench, K.M., Breach, M.R., & Wellman, C.L. (2020). Prior stress followed by a novel stress challenge results in sex-specific deficits in behavioral flexibility and changes in gene expression in rat medial prefrontal cortex. Hormones and Behavior, 117, 104615. PMC6980662.
Breach, M.R., Moench, K.M., & Wellman, C.L. (2019). Social instability in adolescence differentially alters dendritic morphology in the medial prefrontal cortex and its response to stress in adult male and female rats. Developmental Neurobiology, 79, 839-856. PMC6989394.
Godar, S.C., Mosher, L.J., Scheggi, S., Devoto, P., Moench, K.M., Strathman, H. J., Jones, C. M., Frau, R., Melis, M., Gambarana, C., Wilkinson, B., DeMontis, M.G., Fowler, S.C., Coba, M. P., Wellman, C. L., Shih, J. C., Bortolato, M. (2019). Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation. Neuropharmacology, 159, 107513. PMC7578912.
Bollinger, J.L., Salinas, I., Fender, E., Sengelaub, D.R., Wellman, C.L. (2019). Gonadal hormones differentially regulate sex-specific stress effects on glia in medial prefrontal cortex. Journal of Neuroendocrinology, 31, e12762. DOI: 10.1111/jne.12762. PMC6715499.
Alberts, J.A., Harshaw, C., Demas, G.E., Wellman, C.L., & Morrow, A. (2019). The parent-offspring microbiome and neurobehavioral development. Behavioral and Brain Sciences, 42, e62.
Moench, K.M., Breach, M.R., & Wellman, C.L. (2019). Chronic stress produces enduring sex- and region-specific alterations in novel stress-induced c-Fos expression. Neurobiology of Stress, 10, 100147. doi.org/10.1016/j.ynstr.2019.100147.
Wellman, C.L., & Moench, K.M. (2019). Preclinical studies of stress, extinction, and prefrontal cortex: intriguing leads and pressing questions. Psychopharmacology, 236, 59-72. PMC6374178
Wellman, C.L., Bangasser, D.A., Bollinger, J.L., Coutellier, L., Logrip, M.L., Moench, K.M., & Urban, K. (2018). Sex differences in risk and resilience: stress effects on the neural substrates of emotion and motivation. The Journal of Neuroscience, 38(44), 9423–9432. PMC6209838.
Moench, K.M., & Wellman, C.L. (2017). Differential dendritic remodeling in prelimbic cortex of male and female rats during recovery from chronic stress. Neuroscience, 357, 145-159. PMC5555043.
Bollinger, J.L., Collins, K.E., Patel, R., & Wellman, C.L. (2017). Sex differences in- and stress effects on- microglial activation in brain regions critical for emotion regulation and cognitive function. PLOS One,12(12), e0187631. doi.org/10.1371/journal.pone.0187631. PMC5711022.
Moench, K.M., Maroun, M., Kavushansky, A., & Wellman, C.L. (2016). Alterations in neuronal morphology in infralimbic cortex predict resistance to extinction following acute stress. Neurobiology of Stress, 3, 23-33. PMC4730795.
Bollinger, J.L., Burgeon Burns, C.M., & Wellman, C.L. (2016). Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex. Brain, Behavior, and Immunity,52, 88-97. PMC4909118.
Lin, G.L., Borders, C.B., Lundewall, L.J., & Wellman, C.L. (2015). D1 receptors regulate dendritic morphology in normal and stressed prelimbic cortex. Psychoneuroendocrinology, 51, 101-111. PMC4268137.
Moench, K.M., & Wellman, C.L. (2015). Stress-induced alterations in prefrontal dendritic spines: implications for post-traumatic stress disorder. Neuroscience Letters, 601, 41-45.
Godar, S.C., Bortolato, M., Richards, S.E., Li, F., Chen, K., Wellman, C.L., and Shih, J.C. (2015). Monoamine oxidase A enables rapid dendritic remodeling in response to stress. International Journal of Neuropsychopharmacology, 18 (9), 10.1093/ijnp/pyv035. PMC4576521.
Bortolato, M., Godar, S.C., Alzghoul, L., Zhang, Z., Darling, R.D. , Simpson, K.L., Bini, V., Chen, K., Wellman, C.L., Lin, R.C.S. , & Shih, J.C. (2013). Monoamine oxidase A and A/B knockout mice display autistic-like features. International Journal of Neuropsychopharmacology, 16, 869-888. PMC3517692.
Coulon, M., Wellman, C.L., Marjara, I.S., Janczak, A.M., & Zanella, A.J. (2013). Early adverse experience alters dendritic spine density and gene expression in prefrontal cortex and hippocampus in lambs. Psychoneuroendocrinology, 38, 1112-1121.
Maroun M., Ioannides P.J., Bergman K.L., Kavushansky A., Holmes A., Wellman C.L. (2013). Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons. European Journal of Neuroscience, 38, 2611-2620. PMC3773716.
Farrell, M.R., Sengelaub, D.R., & Wellman, C.L. (2013). Sex differences and chronic stress effects on the neural circuitry underlying fear conditioning and extinction. Physiology and Behavior,122, 208–215. PMC3812406.
Wellman, C.L, Camp M., Jones, V.M., MacPherson, K.P., Ihne, J., Fitzgerald, P., Maroun, M., Drabant, E., Bogdan, R., Hariri, A.R., & Holmes, A. (2013). Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. Experimental Neurology, 250C, 260-269. PMC3932627.
Maroun, M., Holmes, A., Wellman, C.L., and Motanis, H. (2012). Enhanced extinction of aversive memories by high-frequency stimulation of the rat infralimbic cortex. PLOS One, 7, e35853.
Camp, M., MacPherson, K.P., Lederle, L., Graybeal, C., Gaburro, S., Debrouse, L., Ihne, J., Bravo, J., O'Connor, R., Ciocchi, S., Wellman, C.L., Lüthi, A., Cryan, J., Singewald, N., & Holmes, A. (2012). Genetic strain differences in learned fear inhibition associate with variation in neuroendocrine, autonomic and amygdala dendritic phenotypes. Neuropsychopharmacology, 37, 1534-1547. PMC3327858.
Wilber, A.A., Walker, A.G., Southwood, C.J., Farrell, M.R., Lin, G.L., Rebec, G.V., & Wellman, C.L. (2011). Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction. Neuroscience, 174, 115-131. PMC3020264.
Christian, K.M., Miracle, A.D., Wellman, C.L., & Nakazawa, K. (2011). Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptors. Neuroscience, 174, 26-36. PMC3020251.
Wilber, A.A., Lin, G.L., & Wellman, C.L. (2011). Neonatal corticosterone administration impairs adult eyeblink conditioning and decreases glucocorticoid receptor expression in the cerebellar interpositus nucleus. Neuroscience, 177, 56–65. PMC3048169.
Martin, K.P., & Wellman, C.L. (2011). NMDA receptor blockade alters stress-induced dendritic remodeling in medial prefrontal cortex. Cerebral Cortex,21, 2366-2373. PMC3697127.
Bortolato, M., Chen, K., Godar, S.C., Chen, G., Wu, W., Rebrin, I., Scott, A.L., Farrell, M.R., Wellman, C.L., & Shih, J.C. (2011). Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology, 36, 2674–2688. PMC3230491.
Mozhui, K., Karlsson, R.-M., Kash, T., Ihne, J., Norcross, M., Patel, S., Farrell, M.R., Hill, E.E., Martin, K.P., Camp, M., Fitzgerald, P., Ciobanu, D., Sprengel, R., Mishina, M., Wellman, C.L., Winder, D., Williams, R.W., & Holmes, A. (2010). Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability. Journal of Neuroscience, 30, 5357–5367. PMC2866495.
Farrell, M.R., Sayed, J.S., Underwood, A.R., & Wellman, C.L. (2010). Lesion of infralimbic cortex occludes stress effects on retrieval of extinction but not fear conditioning. Neurobiology of Learning and Memory, 94, 240-246.
Wilber, A.A., Lin, G.L., & Wellman, C.L. (2010). Glucocorticoid receptor blockade in the posterior interpositus nucleus reverses maternal separation-induced deficits in adult eyeblink conditioning. Neurobiology of Learning and Memory, 94, 263-268. PMC2922459.
Ball, K.T., Wellman, C.L., Miller, B.R., & Rebec, G.V. (2010). Electrophysiological and structural alterations in striatum associated with behavioral sensitization to MDMA (Ecstasy) in rats: role of drug context. Neuroscience, 171, 794–811. PMC2987517.
Wilber, A.A., Southwood, C.J., & Wellman, C.L. (2009). Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats. Developmental Neurobiology, 69, 73-87.
Ball, K.T., Fortenberry, E., Wellman, C.L., & Rebec, G.V. (2009). Sensitizing regimens of (±)3,4-methylenedioxymethamphetamine (ecstasy) elicit enduring and differential structural alterations in the brain motive circuit of the rat. Neuroscience,160, 264–274. PMC2669702.
Holmes, A., & Wellman, C.L. (2009). Stress-induced prefrontal reorganization and executive dysfunction in rodents. Neuroscience and Biobehavioral Reviews, 33, 773–783. PMC2941982.
Garrett, J.E., & Wellman, C.L. (2009). Chronic stress effects on dendritic morphology in medial prefrontal cortex: sex differences and estrogen dependence. Neuroscience,162, 195–207. PMC2720075.
Wilber, A.A., & Wellman, C.L. (2009). Neonatal maternal separation-induced changes in glucocorticoid receptor expression in posterior interpositus interneurons but not projection neurons predict deficits in adult eyeblink conditioning. Neuroscience Letters, 460, 214-218.
Wilber, A.A., & Wellman, C.L. (2009). Neonatal maternal separation alters the development of glucocorticoid receptor expression in the interpositus nucleus of the cerebellum. International Journal of Developmental Neuroscience, 27, 649-654.
Wellman, C.L., Izquierdo, A., Garrett, J.E., Martin, K.P., Carroll, J., Millstein, R., Lesch, K.-P., Murphy, D.L., & Holmes, A. (2007). Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. Journal of Neuroscience, 27, 684-691.
Wilber, A.A., Southwood, C.J., Sokoloff, G., Steinmetz, J.E., & Wellman, C.L. (2007). Neonatal maternal separation alters adult eyeblink conditioning and glucocorticoid receptor expression in the interpositus nucleus of the cerebellum. Developmental Neurobiology,67, 1751-1764.
Miracle, A.D., Brace, M.F., Huyck, K.D., Singler, S.A., & Wellman, C.L. (2006). Chronic stress impairs recall of extinction of conditioned fear. Neurobiology of Learning and Memory, 85, 213-218.
Garrett, J.E., Kim, I., Wilson, R.E., & Wellman, C.L. (2006). Effect of N-methyl-D-aspartate receptor blockade on plasticity of frontal cortex after cholinergic deafferentation in rat. Neuroscience, 140, 57-66.
Garraghty, P.E., Arnold, L.L., Wellman, C.L., & Mowery, T.M. (2006). Receptor autoradiographic correlates of deafferentation-induced reorganization in adult primate somatosensory cortex. Journal of Comparative Neurology, 497, 636–645.
Izquierdo, A., Wellman, C.L., & Holmes, A. (2006). Rapid dendritic retraction in medial prefrontal neurons and impaired fear extinction following exposure to uncontrollable stress. Journal of Neuroscience, 26, 5733–5738.
Kim, I., Wilson, R.E., & Wellman, C.L. (2005). Aging and cholinergic deafferentation alter GluR1 expression in rat frontal cortex. Neurobiology of Aging,26, 1073-1081.
Wood, D.A., Buse, J.E., Wellman, C.L., & Rebec, G.V. (2005). Differential environmental exposure alters NMDA but not AMPA receptor protein expression in nucleus accumbens. Brain Research, 1042, 176-183.
Verhovshek, T., Wellman, C.L., & Sengelaub, D.R. (2005). NMDA receptor binding declines differentially in three spinal motor nuclei during postnatal development. Neuroscience Letters, 384,122-126.
Brown, S.M., Henning, S., & Wellman, C.L. (2005). Short-term, mild stress alters dendritic morphology in rat medial prefrontal cortex. Cerebral Cortex,15, 1714-1722.
Works, S.J., Wilson, R.E., & Wellman, C.L. (2004). Age-dependent effect of cholinergic lesion on dendritic morphology in rat frontal cortex. Neurobiology of Aging, 25, 963-974.
Cook, S.C., & Wellman, C.L. (2004). Chronic stress alters dendritic morphology in rat medial prefrontal cortex. Journal of Neurobiology, 60, 236-248.
Churchill, J.D., Tharp, J.A., Wellman, C.L., Sengelaub, D.R., & Garraghty, P.E. (2004). Morphological correlates of injury-induced reorganization in primate somatosensory cortex. BMC Neuroscience, 5, 43.
Seib, L.M., & Wellman, C.L. (2003). Daily injections alter dendritic spines in rat medial prefrontal cortex. Neuroscience Letters, 337, 29-32.
Harmon, K.M., & Wellman, C.L. (2003). Differential effects of cholinergic lesions on dendritic spines in frontal cortex of young adult and aging rats. Brain Research, 992, 60-68.
Wellman, C.L., Arnold, L.L., Garman E.E., & Garraghty, P.E. (2002). Acute reductions in GABAA receptor binding in layer IV of adult primate somatosensory cortex after peripheral nerve injury. Brain Research, 954, 68-72.
Wellman, C.L. (2001). Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. Journal of Neurobiology, 49, 245-253.
Wellman, C.L., & Pelleymounter, M.A (1999). Differential effects of nucleus basalis lesions in young adult and aging rats. Neurobiology of Aging, 20, 381-393.
Wellman, C.L, Cullen, M.J., & Pelleymounter, M.A. (1998). Effects of controllability of stress on hippocampal pharmacology. Psychobiology, 26, 65-72.
Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Gollub, M., & Wellman, C.L. (1996). The effects of intrahippocampal BDNF and NGF on spatial learning in aged Long Evans rats. Molecular and Chemical Neuropathology, 29, 211-226.
Wellman, C.L., & Sengelaub, D.R. (1995). Alterations in dendritic morphology of frontal cortical neurons after basal forebrain lesions in adult and aged rats. Brain Research, 669, 48-58.
Pelleymounter, M.A., Cullen, M.J., & Wellman, C.L. (1995). Characteristics of BDNF-induced weight loss. Experimental Neurology, 131, 229-238.
Wellman, C.L., Logue, S.F., & Sengelaub, D.R. (1995). Maze learning and morphology of frontal cortex in adult and aged basal forebrain lesioned rats. Behavioral Neuroscience, 109, 1-14.
Wellman, C.L., & Sengelaub, D.R. (1991). Cortical neuroanatomical correlates of behavioral deficits produced by lesion of the basal forebrain in rats. Behavioral and Neural Biology, 56, 1-24.